Enzyme Research
Research from University of California provides new data on enzyme research
Published in TB and Outbreaks Week, September 8th, 2009
Current study results from the report, 'ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria,' have been published. "The ESX-1 secretion system of Mycobacterium tuberculosis delivers bacterial virulence factors to host cells during infection. The most abundant factor, the ESAT-6/CFP-10 dimer, is targeted for secretion via a C-terminal signal sequence on CFP-10 that is recognized by the cytosolic ATPase, Rv3871," scientists writing in the journal Molecular Microbiology report.
"However, the selection determinants for other ESX-1 substrates appear to be more complex. Some substrates, such as ESAT-6, are...
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