Infectious Disease

New infectious disease research from National Institutes of Health outlined

Published in TB and Outbreaks Week, September 22nd, 2009

"sThe role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S. aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by earlier investigators," researchers in the United States report.

"In agreement with other studies that failed to detect similar effects of PVL using community-associated methicillin-resistant S. aureus strains, we found no significant effect of PVL on gene expression or pathogenesis after we repaired the mutation. These findings provide further evidence that PVL does not have a major impact on S. aureus...

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Source: TB and Outbreaks Week (2009-09-22)

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