Life Sciences

Reports outline life sciences research from Yale University

Published in TB and Outbreaks Week, September 22nd, 2009

According to a study from the United States, "Vertebrate immunity to infection enlists a newly identified family of 47-kilodalton immunity-related GTPases (IRGs). One IRG in particular, Irgm1, is essential for macrophage host defense against phagosomal pathogens, including Mycobacterium tuberculosis (Mtb)."

"Here we show that Irgm1 targets the mycobacterial phagosome through lipid-mediated interactions with phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P-2) and PtdIns(3,4,5)P-3. An isolated Irgm1 amphipathic helix conferred lipid binding in vitro and in vivo. Substitutions in this region blocked phagosome recruitment and failed to complement the antimicrobial defect...

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Source: TB and Outbreaks Week (2009-09-22)

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