Tuberculosis

Research on tuberculosis published by scientists at University of Texas

Published in TB and Outbreaks Week, September 22nd, 2009

"There are currently renewed efforts to develop drugs that could shorten the duration of antituberculosis therapy. This is best achieved by optimizing the sterilizing effect," scientists in the United States report.

"However, the current pathway for the development of new molecules with the potential to have a sterilizing effect is inefficient. We designed an in vitro pharmacokinetic-pharmacodynamic model in which Mycobacterium tuberculosis replicating slowly at pH 5.8 was exposed to pyrazinamide by use of the concentration-time profiles encountered in patients. The sterilizing effect rates and the time to the emergence of drug resistance were examined. Daily...

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Source: TB and Outbreaks Week (2009-09-22)

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