Mycobacteria
New mycobacteria research has been reported by scientists at Yeshiva University, Medical Department
Published in TB and Outbreaks Week, September 29th, 2009
"Mycobacterium tuberculosis and other members of the actinomycete family produce mycothiol (MSH or acetylcysteine-glucosamine-inositol, AcCys-GlcN-Ins) to protect the organism against oxidative and antibiotic stress. The biosynthesis of MSH proceeds via a five-step process that involves four unique enzymes, MshA-D, which represent specific targets for inhibitor design," scientists writing in the journal Biochemistry report.
"Recombinant Mycobacterium smegmatis MshC catalyzes the ATP-dependent condensation of glucosamine-inositol (GlcN-Ins) and cysteine to form Cys-GlcN-Ins. The 1.6 angstrom three-dimensional structure of MshC in complex with a tight binding...
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