Tuberculosis

Research conducted at Colorado State University has updated our knowledge about tuberculosis

Published in TB and Outbreaks Week, October 6th, 2009

"Mice infected for 60 days with Mycobocterium tuberculosis were treated with aerosolized XCL1-targeting small interfering RNA (siRNA) to induce local and transient suppression of XCL1/lymphotactin (an important chemokine in tuberculoid granuloma formation)," scientists writing in the American Journal of Respiratory Cell and Molecular Biology report.

"The local pulmonary siRNA therapy resulted in a 50% decrease in the total amount of xcl1 gene transcripts at 3 days, and 40 to 50% protein suppression 3 and 5 days after treatment. Reduced XCL1 expression in the lungs was associated with decreased numbers of T lymphocytes, reduction in the IFN-gamma response,...

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Source: TB and Outbreaks Week (2009-10-06)

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