Legionnaire Disease Cell Biology
Study data from Dalhousie University update knowledge of legionnaire disease cell biology
Published in TB and Outbreaks Week, November 3rd, 2009
New research, 'The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization,' is the subject of a report. "A portion of the total cellular pool of the Legionella pneumophila chaperonin, HtpB, is found on the bacterial cell surface, where it can mediate invasion of nonphagocytic cells. HtpB continues to be abundantly produced and released by internalized L. pneumophila and may thus have postinvasion functions," scientists in Halifax, Canada report.
"We used here two functional models (protein-coated beads and expression of recombinant proteins in CHO cells) to investigate the competence of...
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