Tuberculosis
Studies from S. Chauhan and co-researchers in the area of tuberculosis published
Published in TB and Outbreaks Week, November 10th, 2009
According to recent research from New Delhi, India, "DevR activates the transcription of similar to 48 genes in response to hypoxia and other stresses and triggers metabolic downshift and dormancy development in Mycobacterium tuberculosis. tgs1 and Rv3131 encode triacylglycerol synthase and a putative nitroreductase, respectively, and both are members of the DevR regulon. This study aimed to understand how a single putative DevR binding site identified previously could sustain powerful induction of divergent tgs1-Rv3131 genes."
"DNase I footprinting revealed that phosphorylated DevR in fact binds to two sites symmetrically located at -42.5 and -63.5 bp from...
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