HIV/AIDS Co-Infection

Study results from University of Amsterdam broaden understanding of HIV/AIDS co-infection

Published in TB and Outbreaks Week, November 17th, 2009

According to a study from Netherlands, "Cooperation between different innate signaling pathways induced by pattern-recognition receptors (PRRs) on dendritic cells (DCs) is crucial for tailoring adaptive immunity to pathogens. Here we show that carbohydrate-specific signaling through the C-type lectin DC-SIGN tailored cytokine production in response to distinct pathogens."

"DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1. Mannose-expressing Mycobacterium tuberculosis and human immunodeficiency virus type 1 (HIV-1) induced the recruitment of effector proteins to the DC-SIGN...

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Source: TB and Outbreaks Week (2009-11-17)

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