Enzyme Research

Study data from J. Bender et al provide new insights into enzyme research

Published in TB and Outbreaks Week, November 24th, 2009

"Legionella pneumophila possesses several phospholipases capable of host cell manipulation and lung damage. Recently, we discovered that the major cell-associated hemolytic phospholipase A(PlaB) shares no homology to described phospholipases and is dispensable for intracellular replication in vitro," investigators in Wernigerode, Germany report.

"Nevertheless, here we show that PlaB is the major lipolytic activity in L. pneumophila cell infections and that PlaB utilizes a typical catalytic triad of Ser-Asp-His for effective hydrolysis of phospholipid substrates. Crucial residues were found to be located within the N-terminal half of the protein, and amino acids...

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Source: TB and Outbreaks Week (2009-11-24)

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