West Nile Virus

Studies from National Institutes of Health add new findings in the area of west nile virus

Published in TB and Outbreaks Week, December 29th, 2009

According to recent research from the United States, "Histidine residues have been hypothesized to function as sensors of environmental pH that can trigger the activity of viral fusion proteins. We investigated a requirement for histidine residues in the envelope (E) protein of West Nile virus during pH-dependent entry into cells."

"Each histidine was individually replaced with a nonionizable amino acid and tested functionally. In each instance, mutants capable of orchestrating pH-dependent infection were identified," wrote S. Nelson and colleagues, National Institutes of Health.

The researchers concluded: "These results do not support a requirement...

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Source: TB and Outbreaks Week (2009-12-29)

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