Cytokines

New cytokines study findings reported from University of Verona

Published in TB and Outbreaks Week, January 26th, 2010

"Mtb influences DC activity and T cell-mediated immune responses. We show that the treatment of immature monocyte-derived DC with Mtb elicited the formation of mature DC, producing TNF-alpha, IL-1 beta, IL-6, and IL-23 and instructing CD4(+) cells to secrete IFN-gamma and IL-17," researchers in Verona, Italy report.

"Mtb-induced cytokine release by DC depended on dectin-1 receptor engagement, whereas MR or DC-SIGN stimulation inhibited this process. A selective dectin-1 binding by the receptor agonist glucan was sufficient to enable DC to generate Th1/Th17 lymphocytes, showing features comparable with those induced by Mtb-treated DC. Interestingly, DC-SIGN or MR...

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Source: TB and Outbreaks Week (2010-01-26)

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