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Tuberculosis

Investigators at University of Texas target tuberculosis

Published in TB and Outbreaks Week, February 2nd, 2010

"Pathogenic mycobacteria including Mycobacterium tuberculosis resists phagocyte generated reactive oxygen intermediates (ROI) and this constitutes an important virulence mechanism. We have previously reported, using Mycobacterium smegmatis as a model to identify the bacterial components that resist intracellular ROI, that an antioxidant methionine sulfoxide reductase A (MsrA) plays a critical role in this process," researchers in the United States report.

"In this study, we report the role of methionine sulfoxide reductase B (MsrB) in resistance to ROI by constructing a msrB mutant (MS Delta msrB) and MsrA/B double mutant (MS Delta msrA/B) strains of M. smegmatis and...

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