Enzyme Research

Studies from University of Pennsylvania, Medical Department provide new data on enzyme research

Published in TB and Outbreaks Week, March 16th, 2010

According to a study from the United States, "Poxviruses encode their own type IB topoisomerases (TopIBs), which release superhelical tension generated by replication and transcription of their genomes. To investigate the reaction catalyzed by viral TopIBs, we have determined the structure of a variola virus topoisomerase-DNA complex trapped as a vanadate transition state mimic."

"The structure reveals how the viral TopIB enzymes are likely to position the DNA duplex for ligation following relaxation of supercoils and identifies the sources of friction observed in single-molecule experiments that argue against free rotation. The structure also identifies a...

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Source: TB and Outbreaks Week (2010-03-16)

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