Chemistry

Research reports on chemistry from Chulalongkorn University provide new insights

Published in TB and Outbreaks Week, August 31st, 2010

"The current pandemic of the viral 2009 H1N1 influenza and its sustained human-human transmission has raised global concern for human health. The binding of the viral glycoprotein hemagglutinin (HA) and the human alpha-2,6-linked sialopentasaccharide (SIA-2,6-GAL) host cell receptor is a critical step in the viral replication cycle," scientists in Bangkok, Thailand report.

"Here, the complex structure of the 2009 H1N1 HA bound to the SIA-2,6-GAL sialopentasaccharide receptor was constructed by using homology modeling and molecular dynamic simulations. The receptor was found to fit very well within the HA binding pocket and formed hydrogen bonds with the residues of the...

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Source: TB and Outbreaks Week (2010-08-31)

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