Influenza
Reports on influenza findings from K. Viswanathan and co-researchers provide new insights
Published in TB and Outbreaks Week, November 16th, 2010
"Influenza A viruses, members of the Orthomyxoviridae family, are responsible for annual seasonal influenza epidemics and occasional global pandemics. The binding of viral coat glycoprotein hemagglutinin (HA) to sialylated glycan receptors on host epithelial cells is the critical initial step in the infection and transmission of these viruses," scientists writing in the Glycoconjugate Journal report.
"Scientists believe that a switch in the binding specificity of HA from Neu5Ac alpha 2-3Gal linked (alpha 2-3) to Neu5Ac alpha 2-6Gal linked (alpha 2-6) glycans is essential for the crossover of the viruses from avian to human hosts. However, studies have shown that...
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