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Cholera

Cholera strain evolves new mechanism for causing disease

Published in TB and Outbreaks Week, December 28th, 2010

2010 DEC 28 -- New clinical strains of cholera appear to have evolved a distinctly different mechanism to cause the same disease according to research published in the current issue of the online journal mBio®.

Vibrio cholerae is the causative agent for the diarrheal disease cholera. While there are more than 200 different serogroups only the O1 and the O139 strains have been known to cause epidemic and pandemic outbreaks of disease, using a toxin-coregulated pilus (TCP) and cholera toxin (CT), which other strains lack.

"While non-O1, non-O139 strains have caused sporadic disease globally, the virulence mechanisms are not fully...

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