Genetics and Tuberculosis
Findings from C. Basavannacharya and co-authors provide new insights into genetics and tuberculosis
Published in TB and Outbreaks Week, January 4th, 2011
2011 JAN 4 -- Fresh data on genetics and tuberculosis are presented in the report 'Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis.' "The emergence of total drug-resistant tuberculosis (TDRTB) has made the discovery of new therapies for tuberculosis urgent. The cytoplasmic enzymes of peptidoglycan biosynthesis have generated renewed interest as attractive targets for the development of new anti-mycobacterials," scientists in the United Kingdom report.
"One of the cytoplasmic enzymes, uridine diphosphate (UDP)-MurNAc-tripeptide ligase (MurE), catalyses the addition of meso-diaminopimelic acid (m-DAP)...
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