Tuberculosis
Data from University of Auckland Provide New Insights into Tuberculosis
Published in TB and Outbreaks Week, February 1st, 2011
"This releases toxic reactive nitrogen species which may be responsible for its anti-mycobacterial activity. There are no published reports of mammalian enzymes bioactivating this prodrug. We have investigated the metabolism of PA-824 following incubation with a subcellular fraction of human liver, in comparison with purified Ddn, M. tuberculosis and...
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