Plague
Findings from Z. Ye and Co-Authors Broaden Understanding of Plague
Published in TB and Outbreaks Week, March 15th, 2011
2011 MAR 15 -- "We are using a systemic plague model to identify the cells and pathways that are undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this study, we pursued previous findings that Gr1(+) cells are required to selectively limit growth of Delta yopM Y. pestis and that CD11b(+) cells other than polymorphonuclear leukocytes (PMNs) are selectively lost in spleens infected with parent Y. pestis," scientists in the United States report.
"When PMNs were ablated from mice, Delta yopM Y. pestis grew as well as the parent strain in liver but not in spleen, showing that these cells are critical for controlling growth of...
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