2011 APR 26 -- "We evaluated protection conferred by mucosal vaccination with replication-competent adenovirus-free recombinantadenovirus expressing a codon-optimized avian influenza (AI) H5 gene from A/turkey/WI/68 (AdTW68.H-ck). Commercial, layer-type chicken groups were either singly vaccinated ocularly at 5 days of age, singly vaccinated via spray at 5 days of age, or ocularly primed at 5 days and ocularly boosted at 15 days of age," investigators in Auburn, United States report.
"Only chickens primed and boosted via the ocular route developed AI systemic antibodies with maximum hemagglutination inhibition mean titers of 3.9 log(2) at 32 days of age....
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