Infectious Diseases

Findings from University of Manchester Provide New Insights into Infectious Diseases

Published in TB and Outbreaks Week, July 12th, 2011

2011 JUL 12 -- "An in vitro model of the human alveolus was used to study the impact of minimum inhibitory concentrations (MIC) on exposure-response relationships. The pharmacokinetic-pharmacodynamic relationships of posaconazole were examined in an inhalational murine model of invasive pulmonary aspergillosis," scientists writing in the Journal of Infectious Diseases report.

"A mathematical model was fitted to the entire data set. This model was then used to describe the relationship between drug exposure, quantified in terms of the area under the concentration time curve to MIC (AUC:MIC) and the observed antifungal effect. The posaconazole MIC was...

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Source: TB and Outbreaks Week (2011-07-12)

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