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Pandemics

Research from University of Victoria Provides New Data on Pandemics

Published in TB and Outbreaks Week, November 8th, 2011

2011 NOV 8 -- "Younger age groups account for proportionally more mortality in influenza pandemics than in seasonal influenza epidemics. Mechanisms that might explain this include young people suffering from an over-reactive immune system ('cytokine storm'), older people benefiting from cross-immunity from a wider variety of previous influenza infections ('antigenic history'), and lifetime immune responses in all people being shaped by their first influenza A infection ('antigenic imprinting' or 'original antigenic sin')," scientists writing in the Journal of Theoretical Biology report.

"We examined whether these mechanisms can explain age-specific...

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