Avian Influenza (Bird Flu)

Findings from Kasetsart University Provide New Insights into Avian Influenza (Bird Flu)

Published in TB and Outbreaks Week, February 21st, 2012

2012 FEB 21 -- "Influenza A neuraminidase (NA) is a target for anti-influenza drugs. The function of this enzyme is to cleave a glycosidic linkage of a host cell receptor that links sialic acid (Sia) to galactose (Gal), to allow the virus to leave an infected cell and propagate," researchers in Bangkok, Thailand report.

"The receptor is an oligosaccharide on the host cell surface. There are two types of oligosaccharide receptor; the first, which is found mainly on avian epithelial cell surfaces, links Sia with Gal by an alpha 2,3 glycosidic linkage; in the second, found mainly on human epithelial cell surfaces, linkage is via an alpha 2,6 linkage. Some...

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Source: TB and Outbreaks Week (2012-02-21)

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