Published in TB and Outbreaks Week, March 27th, 2012
"VP24 is known to antagonize interferon signaling by binding host karyopherin a proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription factor STAT1 to the nucleus. Here, we report that VP24 binds STAT1 directly, suggesting that VP24 can suppress at least two distinct branches of the interferon pathway. Here, we also...
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