Tuberculosis
Data from Swiss Institute of Bioinformatics Advance Knowledge in Tuberculosis
Published in TB and Outbreaks Week, May 1st, 2012
2012 MAY 1 -- "In Mycobacterium tuberculosis the alternative sigma factor SigF controls the expression of a particular subset of genes by altering RNA polymerase specificity. Here, we utilize two genome-wide approaches to identify SigF-binding sites: chromatin immunoprecipitation (ChIP-on-chip) and microarray analysis of SigF-mediated transcripts," scientists writing in the Journal of Bacteriology report.
"Since SigF is not an abundant protein in the logarithmic phase of growth, a pristinamyin IA-inducible system was used to control its expression. We identified 67 high-affinity SigF-binding sites and 16 loci where a SigF promoter directs the...
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