University of Sherbrooke

Yeast mRNA-capping enzyme studied, different modes of ligand binding evident

Published in Telemedicine Business Week, March 2nd, 2005

According to recently published research from Canada, the thermodynamics of ligand binding by the yeast mRNA-capping enzyme reveals different modes of binding.

"RNA-capping enzymes are involved in the synthesis of the cap structure found at the 5'-end of eukaryotic mRNAs. The present study reports a detailed study on the thermodynamic parameters involved in the interaction of an RNA-capping enzyme with its ligands," reported I. Bougie and colleagues, University of Sherbrooke.

"Analysis of the interaction of the Saccharomyces cerevisiae RNA-capping enzyme (Ceg1) with GTP, RNA and manganese ions revealed significant differences between the...

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Source: Telemedicine Business Week (2005-03-02)

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