Johnson & Johnson Pharmaceutical Research & Development
Final univariate NIR method can be used to monitor polymorph conversion in wet granulation process
Published in Telemedicine Business Week, February 8th, 2006
"Near infrared (NIR) spectroscopy was used for quantitatively monitoring polymorph conversion of an active pharmaceutical ingredient (A-PI) in wet granulation. The API under pharmaceutical development has two different polymorphs," scientists in the United States report.
W.Y. Li and colleagues, Johnson & Johnson Pharmaceutical Research & Development, wrote, "Polymorph A is the stable form for drug development and polymorph B is the undesired form produced at elevated temperature and humidity.
"Because a reference method...
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