Scientists at Bar-Ilan University, Medical Research Center describe research in adenosine deaminase

New research, "Molecular recognition of adenosine deaminase: 15N NMR studies," is the subject of a report. "The elucidation of the molecular recognition of adenosine deaminase (ADA), the interpretation of the catalytic mechanism, and the design of novel inhibitors are based mostly on data obtained for the crystalline state of the enzyme. To obtain evidence for molecular recognition of the physiologically relevant soluble enzyme, we studied its interactions with the in situ formed inhibitor, 6-OH-purine riboside (HDPR), by 1D-15N-and 2D-(1H-15N)-NMR using the labeled primary inhibitor [15N4]-PR," scientists in Israel report.

"We synthesized both [15N4]-PR and an...

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