Tuberculosis

New tuberculosis research has been reported by H. Yamada et al

Published in Telemedicine Business Week, February 24th, 2010

"Transmission electron microscopy (TEM) of virulent bacteria is usually performed following chemical fixation (CF) with aldehyde fixatives such as glutaraldehyde because of the biosafety problem. However, CF may alter sample ultrastructure," scientists writing in the Journal of Microbiological Methods report.

"In this study, we used a rapid-freeze substitution (RFS) sandwich method without pre-embedding in agar. TEM images obtained using this method were completely different from those of conventional chemically fixed samples; the bacilli cytoplasm of the RFS preparations was filled evenly with numerous ribosomes, and there was no positional variation of electron...

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Source: Telemedicine Business Week (2010-02-24)

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