Malaria Vaccines
Study data from International Center for Genetic Engineering and Biotechnology update understanding of malaria vaccines
Published in Telemedicine Law Weekly, February 24th, 2007
Investigators publish new data in the report "Immunogenicity of a recombinant malaria vaccine based on receptor binding domain of Plasmodium falciparum EBA-175." According to recent research from New Delhi, India, "Malaria parasites require specific receptor-ligand interactions to invade host erythrocytes. The 175 kDa Plasmodium falciparum erythrocyte binding antigen (EBA-175) binds sialic acid residues on glycophorin A to mediate erythrocyte invasion."
"The amino-terminal, conserved, cysteine-rich region of EBA-175, referred to as F2, contains receptor-binding sites. We propose to develop a recombinant malaria vaccine based on region F2. Recombinant P....
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