Chromatography

Research conducted at Technical University of Dresden has provided new information about chromatography

Published in Telemedicine Law Weekly, July 5th, 2008

"A liquid chromatography-tandem mass spectrometric (LC-MS-MS) method was developed for the determination of the neurotropic-musculotropic spasmolytic agent denaverine and five of its metabolites in urine. In a first step P-glucuronidase was used to cleave glucuronides in the human urine," researchers in Dresden, Germany report.

"After that samples containing denaverine and its phase I metabolites were extracted and cleaned up using an automated solid phase extraction method. An external calibration was used. The analytes were measured employing the multiple reaction-monitoring mode (MRM). The linear dynamic range for denaverine and its five metabolites determination was...

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Source: Telemedicine Law Weekly (2008-07-05)

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