Fusion Proteins
Study data from Stanford University update understanding of fusion proteins
Published in Telemedicine Law Weekly, July 5th, 2008
A report, 'Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein,' is newly published data in Molecular Cancer Therapeutics. According to recent research published in the journal Molecular Cancer Therapeutics, "This study used integrin alpha v beta3 as a target for tumor-specific delivery of tumor necrosis factor-alpha (TNF). The fusion protein RGD4C-TNF bound specifically to alpha v beta3 as evidenced by cell receptor binding assay and noninvasive micro-positron emission tomography imaging. 64Cu-DOTA-RGD4C-TNF had significantly higher activity accumulation in integrin-positive tumors (U87MG and MDA-MB-435) but not in integrin-negative tumors (C6) compared with...
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