Chronic Lymphocytic Leukemia Cell Biology
New chronic lymphocytic leukemia cell biology study results reported from Ohio State University, Department of Internal Medicine
Published in Telemedicine Week, April 29th, 2008
New research, 'Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium,' is the subject of a report. "Effective administration of flavopiridol in advanced-stage chronic lymphocytic leukemia (CLL) is often associated with early biochemical evidence of tumor cell lysis. Previous work using other cell types showed that flavopiridol impacts mitochondria, and in CLL cells flavopiridol down-regulates the mitochondrial protein Mcl-1," investigators in the United States report.
"We therefore investigated mitochondrial structure and function in flavopiridol-treated CLL patient...
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Source: Telemedicine Week (2008-04-29)
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