Mass Spectrometry
Scientists at University of Montreal release new data on mass spectrometry
Published in Telemedicine Week, January 19th, 2010
According to a study from Montreal, Canada, "Quantification of 4-hydroxy-2-nonenal (HNE) bound to circulating proteins may prove to be useful in evaluating the role of this bioactive lipoperoxidation by-product in the pathogenesis of various diseases. Recently, we developed a quantitative gas chromatography-mass spectrometry (GCMS) assay of total protein-bound HNE (HNE-P) in blood after reduction with (NaBH4)-H-2 and cleavage with Raney nickel."
"Whereas it has been assumed that Raney nickel cleaves only Michael adducts of HNE to cysteine via a thioether bond (HNE-SP), results from this study demonstrate that our GCMS method also detects with precision picomoles of HNE...
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Source: Telemedicine Week (2010-01-19)
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