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Hematopoiesis

Stem Cells Mediate Engraftment

Published in Transplant Weekly, May 11th, 1998

Stem cells - not committed progenitor cells - mediate the early phase of engraftment, researchers suggested.

Additionally, the absolute number of stem cells in the graft determine the rate of engraftment, indicated J. Mark J.M. Zijlmans, Leiden University Medical Center, Netherlands, and colleagues ("The Early Phase of Engraftment after Murine Blood Cell Transplantation Is Mediated by Hematopoietic Stem Cells," Proceedings of the National Academy of Sciences USA, 1998;95:725-729).

"Our results indicate that hematopoietic stem cells and not committed progenitor cells mediate early hematopoietic reconstitution after blood cell transplantation and that...

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