"Interstitial Cellular and Matrix Restoration of Cardiac Valves After Cryopreservation."

According to the authors' abstract of an article published in Journal of Thoracic and Cardiovascular Surgery, "Objectives: We previously characterized the porcine aortic leaflet interstitial cell phenotype as having both synthetic and contractile characteristics; that is, it is a myofibroblast. In this study we hypothesized (1) that the cryopreservation of aortic valves causes a significant reduction in cell density, (2) that it simultaneously causes alterations in representative components of extracellular matrix, and (3) that both of these processes are reversible. Methods: Seventy-two leaflets from 24 porcine aortic valves were studied. Whole valves were subjected...

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