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Protein Scaffolds
Reports outline protein scaffolds study results from Stockholm University
June 15th, 2009
According to a study from Stockholm, Sweden, "Chlamydia trachomatis R2c is the prototype for a recently discovered group of ribonucleotide reductase R2 proteins that use a heterodinuclear Mn/Fe redox cofactor for radical generation and storage. Here, we show that the Mycobacterium tuberculosis protein Rv0233, an R2 homologue and a potential virulence factor, contains the heterodinuclear manganese/iron-carboxylate cofactor but displays a drastic remodeling of the R2 protein scaffold into a ligand-binding oxidase." "The first structural characterization of the heterodinuclear cofactor shows that the site is highly specific for manganese and iron in their respective...
Source: Tuberculosis Week (2009-06-15)
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