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Tuberculosis
New findings from Virginia Polytechnic Institute in the area of tuberculosis published
June 15th, 2009
"In mycobacteria, F-420, a deazaflavin derivative, acts as a hydride transfer coenzyme for an F-420-specific glucose-6-phosphate dehydrogenase (Fgd). Physiologically relevant reactions in the mycobacteria that use Fgd-generated reduced F-420 (F420H2) are unknown," researchers in the United States report. "In this work, F420H2 was found to be oxidized by NO only in the presence of oxygen. Further analysis demonstrated that NO2, produced from NO and O-2, was the oxidant. UV-visible spectroscopic and NO-sensor-based analyses proved that F420H2 reduced NO2 to NO. This reaction could serve as a defense system for Mycobacterium tuberculosis, which is more sensitive to NO2...
Source: Tuberculosis Week (2009-06-15)
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