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Tuberculosis Cell Biology
Reports from Ohio State University, Center for Microbial Interface Biology advance knowledge in tuberculosis cell biology
June 15th, 2009
Data detailed in 'Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death' have been presented. "The Mycobacterium tuberculosis (M.tb) cell wall contains an important group of structurally related mannosylated lipoglycans called phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM), where the terminal alpha-[1-- >2] mannosyl structures on higher order PIMs and ManLAM have been shown to engage C-type lectins such as the macrophage mannose receptor directing M.tb phagosome maturation...
Source: Tuberculosis Week (2009-06-15)
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