Life Sciences

Research on life sciences discussed by scientists at Madurai Kamaraj University

Published in Tuberculosis Week, March 22nd, 2010

"A series of novel enantiomerically pure spiroisoxazolidines were synthesized regioselectively by the 1,3-dipolar cycloaddition of C-aryl-N-phenylnitrones to ®-1-(1-phenylethyl)-3-[(E)-arylmethylidenejtetrahydro-4(1H)-pyridinones," scientists in Madurai, India report.

"These compounds have been screened for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) using agar dilution method. Among the twenty two compounds screened, (3S,4S,5R)-3,4-di(4-methylphenyl)-2-phenyl-7-[®-1-phenylethyl]-1-oxa-2,7-diazaspiro[4.5]decan-10-one (3e) was found to possess the maximum activity with MIC of 3.02 mc M, being 2.5 times more potent than the first-line...

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Source: Tuberculosis Week (2010-03-22)

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