Vaccine Development

Avoidance of Iron Contamination Crucial in Polyphosphates

Published in Vaccine Weekly, February 27th, 1995

A United Kingdom study finds that polyphosphates bind iron, highlighting the importance of avoiding contamination with iron salt during the production of polyphosphate-type vaccines.

It is known that iron, when present in biological system containing oxygen, can cause substantial structural damage because of the formulation of reactive oxygen species and that this damage is most pronounced in the vicinity of sites which bind the ions (site specific damage).

"The binding of metal ions to macromolecules is nevertheless of considerable biological importance and a convenient method for investigating the phenomenon is by equilibrium dialysis," researcher...

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Source: Vaccine Weekly (1995-02-27)

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