"Mucosal Vaccination Using a Novel Microparticle Delivery System."

According to an abstract submitted by the authors to the Mucosal Immunity: New Strategies for Protection against Viral and Bacterial Pathogens Keystone Symposia, held January 16-23, 1995, in Keystone, Colorado, "Oral vaccination can be accomplished using replicating organisms, certain enterocyte receptor binding immunogens, e.g. cholera toxin or its B subunit, or large and often repeated doses of nonviable or soluble antigens. Although recent reports demonstrate that oral administration of poly(lactidecoglycolide) (PLG) microparticles (MP) can enhance the immunogenicity of soluble antigens, likely by facilitating uptake and controlled release of antigen in the gut-associated lymphoid...

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