Pediatrics

Two-Dose Varicella Vaccine More Effective

Published in Vaccine Weekly, March 13th, 1995

A two-dose course of varicella vaccine appears to offer stronger protection against breakthrough varicella in healthy children than single dose vaccine, but further study is needed to confirm this.

Clinical trials with Oka/Merck varicella vaccine have been ongoing in the United States since 1981. Reinfection or breakthrough illness has occurred in approximately 5 percent of vaccinees and has generally been mild in comparison with natural infection. The incidence of reinfection correlates inversely with the antibody titers documented six weeks after vaccination; this correlation suggests that protection might be even more complete and longer lasting if higher antibody...

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Source: Vaccine Weekly (1995-03-13)

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