"Diversity in the Circumsporozoite Protein of Plasmodium vivax: Does It Matter?."

According to the authors' abstract of an article published in Parasitology Today, "Since the gene encoding the malarial circumsporozoite surface protein was characterized a decade ago, the corresponding protein has been considered an important vaccine candidate. Victoria Mann, Michael Good and Allan Saul here discuss molecular variation in the circumsporozoite surface protein of Plasmodium vivax in this context. There is still doubt about the degree and importance of polymorphisms in non-repetitive regions of the molecule. The degree of polymorphisms and data on naturally occurring protective responses suggest there has been minimal immunological pressure; the authors contend...

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