"Characterization of a Live, Attenuated Human Parainfluenza Type 3 Virus Candidate Vaccine Strain."

According to the authors' abstract of an article published in Journal of Virology, "Characterization of a temperature-sensitive and Live, attenuated human parainfluenza type 3 virus strain (cp45) grown at a permissive temperature (32(degree)C) suggested that the virus efficiently multiplies in cell lines and retains antigenic and functional properties of the envelope glycoproteins. When grown at a nonpermissive temperature (39.5(degree)C), the cp45 virus exhibited poor replication; however, shifting to a permissive temperature allowed virus growth. Although at a nonpermissive temperature virus polypeptide synthesis was significantly reduced, the hemagglutinin-neuraminidase and fusion...

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