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Salk: Low-Dose Immunization May Be Key to HIV Vaccine

Published in Vaccine Weekly, April 3rd, 1995

Low-dose vaccination coupled with antiretroviral therapy might prevent progression to AIDS in people with HIV infection, according to polio vaccine inventor Jonas Salk.

In his keynote lecture to the Third Annual Vaccines: New Technologies and Applications Conference, held March 20-22 in Alexandria, Virginia, Salk recommended testing a strategy for AIDS therapy that would take advantage of the potential synergy between immune-based and antiretroviral treatments. He suggested that immunization designed to elicit functional cell-mediated memory could be combined with antiretroviral agents to decrease viral burden.

"The two together could result in the...

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