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Animal Models

Newborn Primates Die when Immunized with SIV

Published in Vaccine Weekly, April 3rd, 1995

A candidate AIDS vaccine that works well on adult monkeys is a killer when given to newborns - a setback in efforts to find vaccine formulas that protect against the deadly virus.

Researchers at Dana-Farber Cancer Institute found that a genetically altered live virus that protects adult monkeys from a simian AIDS virus actually will cause newborn monkeys to sicken and die of the disease, according to a study published in the March 24, 1995, issue of the journal Science.

"The study shows that the virus has not lost its ability to cause AIDS even after we removed the genes," said Dr. Ruth Ruprecht, chief of the laboratory of viral pathogenesis at...

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