Immunology

V3 Loop in HIV gp120 Induces env-Specific CTL

Published in Vaccine Weekly, April 3rd, 1995

Carrier free 10-amino acid synthetic peptide from the V3 loop region in HIV-1 gp120 has the optimal sequence for efficient induction of HIV env-specific cytotoxic T lymphocytes in mice, according to a report from the University of Texas M.D. Anderson Cancer Center.

Researcher Pramod N. Nehete and colleagues previously reported the induction of major histocompatibility complex (MHC) class I-restricted, CD8 cytotoxic T lymphocytes (CTLs) specific to HIV-1 in mice by a 15-amino acid peptide (R15K) from the V3 loop in gp120.

In this study Nehete et al. present evidence suggesting that CTL activity induced by R15K was stable for eight to 10 weeks...

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Source: Vaccine Weekly (1995-04-03)

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