Vesicular Stomatitis Virus

VSV-Specific IgG Atnibodies Analyzed

Published in Vaccine Weekly, April 3rd, 1995

Studies designed to assess the time- and dose-dependent neutralizing antibody responses against vesicular stomatitis virus suggest that these antibodies recognize only one major antigenic site on the viral glycoprotein.

Vesicular stomatitis virus (VSV) is closely related to rabies virus and can infect many species. Neutralizing IgG antibody responses specific for the viral glycoprotein of rabies virus or VSV are necessary for and efficient in protecting vertebrate hosts against infection.

"Interestingly, naive specific pathogen-free or conventionally kept mice generate T-cell-independent neutralizing IgM antibodies very early after infection, by day...

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Source: Vaccine Weekly (1995-04-03)

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